Posts Tagged ‘adolescents’

FDA Approves Once Weekly Drug for Diabetes; Shows Weight Loss

January 28th, 2012

The Food and Drug Administration has approved Amylin Pharmaceutical’s Bydureon for thetreatment of type 2 diabetes. This is the first once-weekly treatment for type 2 diabetes. It is hoped that this feature will lead to higher adherence to the treatment regimen, although as with Byetta, it is injectable. The drug is exenatide, a GLP-1 receptor agonist. Study results showed an improvement in glycemic control.  A1C levels, a measure of blood sugar, decreased an average of 1.6 points.

Many patients with Type 2 diabetes are also overweight or obese. Many drugs for type 2 diabetes actually cause weight gain. The advantage of Bydureon (and its daily administered counterpart, Byetta) is that patients taking Bydureon can achieve weight loss, in addition to improvements in glycemia, blood pressure, and cholesterol in both overweight and obesity subjects with and without type 2 diabetes. Effects of glucagon-like peptide-1 receptor agonists on … [BMJ. 2012] – PubMed – NCBI

A very small study of 12 children and adolescents with extreme obesity also showed significant improvements, suggesting the need for a larger study. Exenatide as a weight-loss therapy i… [Obesity (Silver Spring). 2012] – PubMed – NCBI

More information is available at www.BYDUREON.com.

Bariatric Surgery for Teens on the Rise

December 27th, 2011

A new study shows a dramatic increase in bariatric surgery for adolescents. The procedures have changed with an increase in gastric banding and a decrease in gastric bypass. Side effects and mortality remain small in this study of academic medical centers. Increasing utilization of laparoscopic gastric bandi… [Am Surg. 2011] – PubMed – NCBI

American Heart Assn. Sees Tidal Wave of Cardiovascular Disease coming from Obesity Epidemic

December 16th, 2011

The American Heart Association has published an update on the burden of cardiovascular disease and stroke. They warn that the recent drop in death rates is likely to be reversed by the continuing increases in the rates of diabetes and obesity. Dr. Donald Lloyd-Jones told MedPageToday  that rising death rates in cardiovascular death in young adults is particularly troubling, “Because if they’re getting disease at this young of an age then they’re just the leading edge – the canaries in the coal mine, if you will – that suggests that we have a whole tidal wave of cardiovascular disease that is coming as a result of the obesity epidemic.” Medical News: Diabetes, Obesity Overshadow Lower CV Death Rate – in Cardiovascular, Prevention from MedPage Today 

Here are the facts:

The estimated prevalence of overweight and obesity in US adults (>20 years of age) is 149 300 000, which represents 67.3% of this group in 2008. Fully 33.7% of US adults are obese (body mass index >30 kg/m2). Men and women of all race/ethnic groups in the population are affected by the epidemic of overweight and obesity.

● Among children 2 to 19 years of age, 31.9% are overweight and obese (which represents 23 500 000 children), and 16.3% are obese (12 000 000 children). Mexican American boys and girls and African American girls are disproportionately affected. Over the past 3 decades, the prevalence of obesity in children 6 to 11 years of age has increased from <4% to more than 20%.

● Obesity (body mass index >30 kg/m2) is associated with marked excess mortality in the US population. Even more notable is the excess morbidity associated with overweight and obesity in terms of risk factor development and incidence of diabetes mellitus, CVD end points (including coronary heart disease, stroke, and heart failure), and numerous other health conditions, including asthma, cancer, degenerative joint disease, and many others.

● The prevalence of diabetes mellitus is increasing dramatically over time, in parallel with the increases in prevalence of overweight and obesity.

● On the basis of NHANES 2003–2006 data, the age adjusted prevalence of metabolic syndrome, a cluster of major cardiovascular risk factors related to overweight/obesity and insulin resistance, is 34% (35.1% among men and 32.6% among women).

● The proportion of youth (<18 years of age) who report engaging in no regular physical activity is high, and the proportion increases with age. In 2007, among adolescents in grades 9 through 12, 29.9% of girls and 17.0% of boys reported that they had not engaged in 60 minutes of moderate-to-vigorous physical activity, defined as any activity that increased heart rate or breathing rate, even once in the previous 7 days, despite recommendations that children engage in such activity >5 days per week.

● Thirty-six percent of adults reported engaging in no vigorous activity (activity that causes heavy sweating and a large increase in breathing or heart rate).

● Data from NHANES indicate that between 1971 and 2004, average total energy consumption among US adults increased by 22% in women (from 1542 to 1886 kcal/d) and by 10% in men (from 2450 to 2693 kcal/d;

● The increases in calories consumed during this time period are attributable primarily to greater average carbohydrate intake, in particular, of starches, refined grains, and sugars. Other specific changes related to increased caloric intake in the United States include larger portion sizes, greater food quantity and calories per meal, and increased consumption of sugar-sweetened beverages, snacks, commercially prepared (especially fast food) meals, and higher energy-density foods.

For the full report, see Heart Disease and Stroke Statistics—2011 Update1. About 1. About These Statistics2. American Heart Association’s 2020 Impact Goals3. Cardiovascular Diseases4. Subclinical Atherosclerosis5. Coronary Heart Disease, Acute Coronary Syndrome, and Angina Pectoris6.

Nation’s Obesity Strategy a Failure

October 7th, 2011

The Department of Health and Human Services has issued its 10 year review of the nation’s health care goals, set in 2000. For obesity the picture is not pretty. By direct measurement between 1988-94 and 2005-8, adults over 20 with obesity increased by nearly 47.8%. The target for 2010 was 15%. Children and adolescent rates increased by 63.5% from 11% to 18%. The 2010 target was 5%.  The report also not little to no progress on increasing the proportion of adults or adolescents engaged in regular vigorous physical activity.  Finally, the proportion of adults 20 and over at a healthy weight, directly measured, decreased by 26%; in 2008 only 31% of American adults were at a health weight, the Healthy People goal was 60%. The proportion of persons with healthy eating habits showed no change, still below targets.

CDC – National Center for Health Statistics Homepage

It has to be recognized that during this period millions of dollars have been spent in the public and private sector on educating the public on obesity and the message to ‘eat less and exercise more’ (ELEM).  One would think that this dismal outcome would encourage a critical reappraisal of the nation’s anti-obesity strategy. Alas, I wish it were so. I suspect that we will see merely a call to shout ELEM louder.

Is obesity leveling off and what does it matter?

January 23rd, 2010

Ten days ago, the media was touting new reports from the CDC that the obesity epidemic was ‘leveling off’ or  ‘reaching a plateau.’ The news was taken in some quarters with a sense of relief:”Whew, I’m glad that’s over.” Well, don’t get too comfortable. The reports have a lot more to say and overall, this is not a time for complacency.

What the reports actually say.

First, regarding adults, (Prevalence and trends in obesity among US adults, … [JAMA. 2010] – PubMed result), the authors note that the prevalence of obesity is high, exceeding 30% in most age and sex groups except for men 20-39 years old. Strong racial and ethnic differences persist with very high rates among African-American and Hispanic Americans compared to white Americans. Prevalence of severe or morbid obesity, called class 3, (a BMI of 40 or more) was 5.7% overall, with 4.2% for mean and 7.2% for women, including a rate of 14.2% among non-Hispanic black women. What their analyses found was that the earlier rates of increase were on the order of 6 to 7 percentage points. In the this analysis, over the past ten years, the rate of increase is 4.7 percent. Bottom line: rates are still going up.

Second, regarding children, (Prevalence of high body mass index in US children … [JAMA. 2010] – PubMed result) the authors found no statistically significant increases over the last 10 years among girls. Among boys, there is a different picture. Heavy boys between 6 and 19 years of age are getting heavier. Bottom line: the prevalence of obesity has tripled among school-age children and adolescents if you go back to the 1980s. It is high – 17%- and remains high.

So, is the epidemic leveling off? Answer: we don’t know yet. These analyses look at the last ten year trends and they are less than the peak periods of increase. Is this a pause on an upward track or the start of a decline?

Experts I talked with are not too optimistic. First, there is the perennial question of relying on the BMI. A recent paper indicates that more precise tools, like skinfold tests, would have predicted the obesity epidemic by 10-20 years. The timing of the rise in U.S. obesity varies with… [Econ Hum Biol. 2009] – PubMed result. Second, there isn’t a clear explanation of why the rates should be leveling off. We’d like to think people are changing their behavior but the evidence is there is less compliance with recommended dietary and physical activity standards than ever. Adherence to healthy lifestyle habits in US adults… [Am J Med. 2009] – PubMed result  Compliance with the DASH diet among persons with hypertension has slipped. Deteriorating dietary habits among adults with hyp… [Arch Intern Med. 2008] – PubMed result

The recession may be causing people to forgo buying more expensive but healthier foods Recession Weighs on Waistlines – chicagotribune.com. Many clinicians running medical weight management programs I have talked with report their volume is down 20-30%.

Hopefully, this is the beginning of a levelling or downard trend in obesity but we will not know for sure until more information comes in. In the meantime, we should consider that we don’t to be having phenomenal increases in obesity to justify more programs for treatment and prevention. An editorial  by J Michael Graziano on the two reports from CDC, states, “Even if these trends can be maintained, 68% of US adults are overweight or obese, and almost 32% of school-aged US children and adolescents are at or above the 85th percentile of BMI for age. Given the risk of obesity-related major health problems, a massive public health campaign to raise awareness about the effects of overweight and obese is necessary..Major research initiatives are needed to identify better management and treatment options. The longer the delay is taking aggressive action, the higher the likelihood that the significant progress achieved in decreasing chronic disease rates during the last 40 years will be negated, possibly even with a decrease in life expectancy.”  Amen.

Bariatric Surgery

September 27th, 2009

Centers of Excellence Programs Surgical Review Corporation

NIH: WIN – Publication – Bariatric Surgery for Severe Obesity

An unique, new study found that maternal weight loss from bariatric surgery may improve cardiometabolic  risks in infants which is sustained into adulthood.Effects of Maternal Surgical Weight Loss in Mother…[J Clin Endocrinol Metab. 2009] – PubMed Result

 

Health Outcomes of Gastric Bypass Patients Compare…[Obesity (Silver Spring). 2009] – PubMed Result

Two-year changes in health-related quality of life…[Surg Obes Relat Dis. 2009 Mar-Apr] – PubMed Result

Health and health-related quality of life: differe…[Surg Obes Relat Dis. 2008 Sep-Oct] – PubMed Result

Review of meta-analytic comparisons of bariatric s…[Surg Obes Relat Dis. 2008 May-Jun] – PubMed Result

Change in predicted 10-year cardiovascular risk fo…[Obes Surg. 2009] – PubMed Result

Complications and Costs for Obesity Surgery Declining

Bariatric surgery and reduction in morbidity and m…[Int J Obes (Lond). 2008] – PubMed Result

Bariatric Surgery in Adolescents

An update on 73 US obese pediatric patients treate…[J Pediatr Surg. 2008] – PubMed Result

Bariatric surgery for severely obese adolescents. [J Gastrointest Surg. 2003] – PubMed Result

Best practice updates for pediatric/adolescent wei…[Obesity (Silver Spring). 2009] – PubMed Result

Counseling

September 27th, 2009

Using web-based approachWeb-based Weight Loss in Primary Care: A Randomize…[Obesity (Silver Spring). 2009] – PubMed Result

Preventing weight gain among new mothers Weight, physical activity and dietary behavior cha…[Nutr J. 2009] – PubMed Result . See also Preventing weight gain: the baseline weight relate…[BMC Public Health. 2009] – PubMed Result, and Health Hunters–an intervention to prevent overwei…[Int J Obes (Lond). 2006] – PubMed Result

Modest benefits of community cardiovascular prevention program in women Outcomes of National Community Organization Cardio…[J Cardiovasc Transl Res. 2009] – PubMed Result

Primary Care Treatment of obesity in primary care practice in t…[J Gen Intern Med. 2009] – PubMed Result

Weight loss advice U.S. obese adults receive from …[Prev Med. 2008] – PubMed Result

Are healthcare professionals advising obese patien…[MedGenMed. 2005] – PubMed Result

Psychological interventions for overweight or obes…[Cochrane Database Syst Rev. 2005] – PubMed Result

Downey Fact Sheet 4 – The Global Obesity Epidemic

September 27th, 2009

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Increasing rates of obesity are not unique to the United States. Rates of obesity are increasing around the globe.

By Julie Snider for the Downey Obesity Report

By Julie Snider for the Downey Obesity Report

The World Health Organization projects at, as of 2005, 1.6 billion adults were overweight and at least 400 million were obese. Approximately 2.3 billion adults will be overweight and 700 million will be obese by 2015. WHO | Obesity and overweight

The Global Prevalence of Obesity is tracked by the International Obesity Task Force, a wealth of data is available at ..:: IOTF.ORG – International Obesity Taskforce ::..

The prevalence of obesity among children is increasing worldwide. Worldwide trends in childhood overweight and obesi…[Int J Pediatr Obes. 2006] – PubMed Result

The increasing trends worldwide appear to affect the children from higher, not lower, socioeconomic status Obesity among pre-adolescent and adolescents of a …[Asia Pac J Clin Nutr. 2004] – PubMed Result

Prevalence is also increasing in Europe The epidemic of obesity in children and adolescent…[Cent Eur J Public Health. 2006] – PubMed Result

In India, undernutrition and obesity are co-occuring. Patterns, distribution, and determinants of under-…[Am J Clin Nutr. 2006] – PubMed Result

The cause appears to reflect dramatic changes in diet in urban areas and in reductions in physical activity The nutrition transition and obesity in the develo…[J Nutr. 2001] – PubMed Result. Some of the effects may be due to changes in income levels. Rapid income growth adversely affects diet quality…[Soc Sci Med. 2004] – PubMed Result. See also, Poverty and obesity: the role of energy density an…[Am J Clin Nutr. 2004] – PubMed Result and The real contribution of added sugars and fats to …[Epidemiol Rev. 2007] – PubMed Result

As one would expect, the worldwide incidence of diabetes is also increasing Global Prevalence of Diabetes — Diabetes Care