Posts Tagged ‘birth defects’

Study Links Autism to Obesity, Diabetes

May 19th, 2012

The increasing prevalence of autism spectrum disorders (ASD) has been both controversial and concerning to parents and health professionals. Could obesity and type 2 diabetes be responsible for some of the increase?

In a  paper in the May 2012 Pediatrics, researchers from the CHARGE (Childhood Autism Risks from Genetics and Environment) study in California, looked to see if metabolic conditions, specifically type 2 diabetes, hypertension and obesity, in mothers during pregnancy were associated with ASD or developmental delays (DD) in offspring. The study involved 517 children with ASD, 172 DD, and 315 controls. The researchers found that all metabolic conditions were more prevalent among mothers with affected children. Collectively, these conditions were associated with a higher likelihood of risk of ASD and DD relative to controls (odds ratio 1.61 and 1.10, respectively).

The authors state, “In a diabetic and possibly prediabetic pregnancy, poorly regulated maternal glucose can result in adverse fetal development. “  Concluding, they point out, “The prevalence of obesity and diabetes among US women of childbearing age is 34% and 8.7% respectively. Our findings raise concerns that these maternal conditions may be associated with neurodevelopmental problems in children and therefore could have serious public health implications. PubMed: Maternal Metabolic Conditions

Vivus Inc. Announces Date for FDA AdCom; results of birth defect study

December 23rd, 2011

Vivus Inc. has announced that the FDA will hold an   Advisory Committee meeting on February 22, 2012 for review of the obesity treatment, Qnexa. VIVUS, Inc. – VIVUS Announces Date of FDA Advisory Committee Review of Qnexa for the Treatment of ObesityTwo days ago, Vivus Inc. released resulted of the FORTRESS study.  The study looked retrospectively at women delivered infants while taking topiramate, one of the two active drugs in Qnexa. Compared to women who had taken topiramate earlier but not during their current pregnancy, those taking topiramate during pregnancy reported a higher rate of cleft palates in their children (0.29% v. 0.16%) VIVUS, Inc. – VIVUS Reports Topline Findings From FORTRESS An earlier study unrelated to topiramate reported a higher rate of birth defects overall and cleft palate, in particular, in women with obesity compared to women of normal weight.

The company’s current application would limit distribution to men and women beyond child-bearing age.

Study Raises Prospect of Qnexa Approval

December 15th, 2011

A study published December 7, 2011in the American Journal of Clinical Nutrition provides two-year data on the safety and effectiveness of Vivus Inc.’s drug candidate, Qnexa in patients with cardiometabolic disease.

Qnexa is a combination drug composed of phentermine and topiramate. It was tested in two doses among 676 subjects. Changes in weight were -1.8% for placebo, -9.3% for low dose and -10.5% for the high dose. Significantly more subjects at each dose achieved more than 5%, 10%, 15% and 20% weight loss compared to placebo. Subjects on the drug had improved cardiovascular and metabolic metrics and decreased rates of diabetes. The high dose was significantly better in weight loss among the most severely obese subjects. Adverse events were modest and drop-out rates were similar between placebo and drug groups. There were no deaths. There were two pregnancies. One was carried to term. The other resulted in a miscarriage. The infant was born with no observed birth defects which was a concern of the FDA Advisory Committee which reviewed the drug last year.Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study 

The very impressive weight loss and low side effect profile from this two-year study are expected to improve the odds of approval by the FDA. Another Advisory Committee hearing in early 2012 is expected. 

FDA, Qnexa and Birth Defects

September 23rd, 2011

Since the FDA pried open the doors for Vivus and Orexigen to have a second bite at approval for their anti-obesity drugs, researchers and clinicians have seen some hope for approval on the horizon and investors have pushed their stock prices up. But they still have many obstacles to overcome. On September 23, 2011, the FDA Pediatric Advisory Committee reviewed safety information for topirmate, which, with phentermine, is one of the two ingredients in Vivus’s drug, Qnexa ®. One of the FDA’s reviews, Topirmate’s Use During Pregnancy, provides some insights into issues the FDA will be looking at down the road. 

The bottom line is that the review indicates topiramate contributes to an elevated risk of oral clefts and to decreased fetal weight at birth. The report notes that topiramate is used off-label for weight loss purposes but the exact mechanism is not known. The hypothesized mechanism is increased energy expenditure secondary to anorexia; reduction in the activity of salivary enzymes (which are partially responsible for taste); reduction in leptin and corticosteroid concentrations) and reduction in blood glucose and insulin concentrations. The reviewer comments, “ The off-label use of topiramate for weight-loss is particularly concerning, as it would presumably be prescribed to a wider population of women of childbearing age than for epilepsy and migraine. In addition, the practitioners prescribing topiramate for weight loss may not be as familiar with its safety profile as a neurologist, and therefore less likely to counsel patients on potential pregnancies.”

The review examines pregnancies in the Qnexa development program, noting that the data are confounded as phentermine, the other component, is classified as a Pregnancy Category C, which may also contribute to malformations. There were 34 pregnancies during the Qnexa trials despite instructions to use two forms of  birth control, noting that this is consistent with previous evidence that such instructions are “not strictly followed by patients.” Of the 34 pregnancies, there were 18 live births and no anomalies.  However, one pregnancy was on-going at the time of the NDA submission. The fetus has been diagnosed with Down’s syndrome via pre-natal testing, including amniocentesis. The review concludes that the division found the relationship of topiramate and oral clefts was probably causal and was described in the labeling but the low birth weight and hypospadias had insufficient evidence for monitoring. http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/PediatricAdvisoryCommittee/UCM272371.pdf

Beyond the scope of this FDA review (but hopefully not of the review for Qnexa for the next Advisory Committee) is the issue of birth defects, specifically cleft palates in children of mothers who are obese. This has been a topic of major concern with some studies showing a relationship and some studies not supporting such a relationship. A recent study of 229,328 Swedish women between their first two pregnancies showed that those whose second-pregnancy weight gain was 3 or more BMI units higher than their first-pregnancy weight gain had a 2.3 times higher risk of having a child with cleft palate compared with women whose BMI did not change substantially. The incidence of cleft palate also increased with the length of the interpregnancy interval. Risk of Oral Clefts in Relation to Prepregnancy Weight Change and Interpregnancy Interval

Of course this issue can affect a future FDA review. Do you look at a drug’s side effect, in this case cleft palate, comparing women with obesity on the drug to normal weight women not taking the drug or to women with obesity not taking the drug? This could significantly change the baseline prevalence of such birth malformations.  On the other hand, what are the benefits in terms of fertility and reduction in birth defects for women of child bearing age who achieve significant weight loss. Unfortunately, the data is limited to bariatric surgery and is not overwhelming but a review in the Journal of the American Medical Association in 2008 pointed strongly to improvements in both categories. Pregnancy and fertility following bariatric surgery: a … [JAMA. 2008] – PubMed – NCBI   Will these benefits be weighed by the FDA in their future risk-benefit calculus? Only time will tell.

Archives

September 27th, 2009

APRIL 2009

April 24, 2009

After planting garden, Michelle Obama skips out to Five Guys for a burger.

First lady says she sneaks off to fun restaurants – washingtonpost.com

MARCH 2009

March 31, 2009

Kansas Governor Kathleen Sebelius lead off her testimony to the Senate Health, Education, Labor, and Pensions Committee stating, “Yet, at the beginning of the 21st century, we face new and equally daunting challenges.

We face an obesity epidemic that threatens to make our children the first generation of Americanchildren to face life expectancies shorter than our own.”

March 30, 2009

Review of new drugs for obesity Obesity Drug by Arena Has an Effect, but a Limited One – NYTimes.com

March 27, 2009

New York Times reports on walking school buses in Italy fighting obesity and climate change

Students Give Up Wheels for Their Own Two Feet – NYTimes.com

March 18, 2009

Another study shows obesity increases risk of death

Obesity Takes Years Off Your Life – Forbes.com

March 13, 2009

Mississippi to cover state workers’ bariatric surgery

Surgery: Long-term care is more expensive | clarionledger.com | The Clarion-Ledger

March 9, 2009

Obama sets out Administration policy on use of science The White House – Press Office – Memorandum for the Heads of Executive Departments and Agencies 3-9-09

March 6, 2009

Abdominal obesity adversely affects lung function Belly Fat Bad for Your Lungs?

March 6, 2009

New study finds dietician students prejudiced against persons with obesity Bias Against Obesity Is Found Among Future Dietitians – Forbes.com

March 1, 2009

Obesity increases worker’s comp. Obesity supersizing workers comp costs – Financial Week

March 1, 2009

South Carolina Senator criticized for trying to dump bicycle paths from stimulus bill. DC Bicycle Transportation Examiner: Sen. DeMint’s pro-obesity legislation was the real pork in the stimulus debate

FEBRUARY 2009

February 27, 2009

Obama budget to cut farm subsidies; improve child nutrition Obama wants to cut subsidies to farmers | DesMoinesRegister.com | The Des Moines Register

February 27, 2009

Drug maker buries data on diabetes drug causing weight gain AstraZeneca Documents Released in Seroquel Suit – NYTimes.com

February 20, 2009

North Carolina looks to penalize persons with obesity: Smoking, obesity may cost state employees | CharlotteObserver.com

February 19, 2009

Robert Wood Johnson Foundation announces national effort on childhood obesity Leading Research Funders Launch Collaborative To Accelerate Nation’s Progress in Reducing Childhood Obesity – RWJF

February 19, 2009

Clinton Foundation announces alliance on childhood obesity Alliance for a Healthier Generation Expands Efforts to Combat Childhood Obesity with Launch of Landmark Healthcare Initiative

February 18, 2009

Court of Appeals upholds NYC Calorie Disclosure Ordinance

http://www.citizen.org/documents/NYSRAOpinion.pdf

Court Upholds the City’s Rule Requiring Some Restaurants to Post Calorie Counts – NYTimes.com

CDC: Young Invincibles are obese CDC: ‘Young invincibles’ have significant health concerns – CNN.com

February 16, 2009:

Home recipes increase in calories: ‘Joy of Cooking’ or ‘Joy of Obesity’? – Los Angeles Times

February 12, 2009

CMS Issues decision on using bariatric surgery to treat Type 2 Diabetes; notes effectiveness of bariatric surgery in resolving Type 2 Diabetes. Centers for Medicare & Medicaid Services

Obesity linked to Birth Defects

Obesity During Pregnancy Linked to Infant Birth Defects – NYTimes.com

JAMA paper on birth defect risks with mothers with obesity. JAMA — Maternal Overweight and Obesity and the Risk of Congenital Anomalies: A Systematic Review and Meta-analysis, February 11, 2009, Stothard et al. 301 (6): 636

February 19, 2009

Fast food restaurants predict strokes

More Fast-Food Joints in Neighborhoods Mean More Strokes – US News and World Report

February 12, 2009

How evolution lead to modern obesity

AAAS: Modern obesity epidemic can be traced back two million years – Telegraph

NEJM — Expanding Coverage for Children — The Democrats’ Power and SCHIP Reauthorization

JANUARY 2009

January 24, 2009

Childhood obesity influenced by genetic variations

Science Centric | News | Childhood obesity risk increased by newly-discovered genetic mutations

January 21, 2009

Obesity imperils health care reform

FEATURE-U.S. obesity epidemic shows perils to health reform – Forbes.com

January 20, 2009

Employers try incentives for healthier workforce Firms offer bigger incentives for healthy living – USATODAY.com

January 13, 2009

NIH launches study of how genes and environment affect children’s development National Children’s Study Begins Recruiting Volunteers, January 13, 2009 News Release – National Institutes of Health (NIH)

January 9, 2009

Physical Activity May not be Key to Obesity After All

Physical Activity May Not Be Key To Obesity Epidemic

January 6, 2009

Obesity and Ovarian Cancer Linked

Obesity Linked To Elevated Risk Of Ovarian Cancer

DECEMBER 2008

December 22, 2008

A little overweight and inactive hurts too

Even a Little Overweight, Inactivity Hurts the Heart – washingtonpost.com

December 19, 2008

Limiting snacks in schools can increase fruit, veggie consumption

Limiting School Snacks Boosts Fruit, Veggie Consumption – US News and World Report

December 18, 2008

Childhood Obesity may affect thyroid

Childhood Obesity May Cause Thyroid Problems – washingtonpost.com

December 16, 2008

New York Debates Tax on Soft Drinks

A Tax on Many Soft Drinks Sets Off a Spirited Debate – NYTimes.com

December 12, 2008

Study looks at relationship between obesity, breast cancer and frequency of mammography

Daily Cancer News – CancerConsultants.com

December 3, 2008

Visceral obesity linked to depression in elderly

Depression Linked to Increase in Abdominal Fat – US News and World Report

Health Effects

September 26th, 2009

Obesity is now recognized as one of America’s most serious and growing epidemics. As expected, the prevalence of numerous, adverse health conditions flowing from obesity has also increased. For some of these conditions, obesity appears to be a strong causal factor, others are mentioned in the literature as associations or as causing additional complications: asthma, birth defects, certain cancers (such as breast, esophagus, gastric cardia, colorectal, endometrial, kidney, ovarian, pancreatic, prostate and renal cell), chronic venous insufficiency, congestive heart failure, coronary artery disease, deep vein thrombosis, end-stage renal disease, erectile dysfunction, gallbladder disease, gastroesophageal reflux disease (GERD), gout, fatty liver disease also called NASH, heat disorders, hypertension, hypercholesteremia, impaired respiratory function, infections following wounds, infertility, kidney disease, low back pain, macular degeneration, metabolic syndrome, migraine, gynecological complications, osteoarthritis, pancreatitis, polycystic ovary syndrome, pseudotumor cerebri or benign intracranial hypertension, psoriasis, sleep apnea, stroke and urinary stress incontinence and urinary tract infections. Obesity is often accompanied by psychosocial problems and outright stigmatization and discrimination. Low self-esteem and disability are obesity’s handmaidens.

The health effects of morbid obesity may be understated. A recent study found that employees with morbid obesity have a significantly higher prevalence of more than 100 diseases and conditions compared with other employees, and that those who had bariatric surgery had reduced the prevalence of one quarter of them. According to the lead author, “Morbid obesity appears to be a common link between a wide variety of conditions. This study suggests employers who implement effective prevention and treatment strategies for morbid obesity itself could have a major impact on the overall health of their employees.” New Study Shows Morbidly Obese Workforce Has Higher Prevalence of 100+ Diseases and Conditions

The following are numerous health effects associated with obesity. This is not intended as an exhaustive listing of conditions. Some may be inadvertently omitted. In some cases, the relationship between obesity and the condition are well established. Conditions also vary in how powerful a factor obesity might be. Type 2 diabetes, dislipidemia, obstructive sleep apnea, breathlessness, the obesity hypoventilation syndrome, indiopathic intercranial hypertension and nonalcoholic steatohepatitis have the strongest association with obesity. The effect of obesity on health outcomes. [Mol Cell Endocrinol. 2009] – PubMed Result

Several conditions are in very early stages of research and the connection with obesity may be disproved. Some of the associations with obesity or overweight are quite strong, less so in others. The incidence of co-morbidities related to obesity…[BMC Public Health. 2009] – PubMed Result The links are principally to peer-reviewed, published articles. Where possible, the first link is to a newspaper or magazine article on the subject. The articles are not meant to be comprehensive on the topic but merely to enable the reader who is interested in getting started. Where possible, the links are to review articles which summarize the available studies. Governmental statements are included where available as well as professional consensus statements or treatment guidelines. Whenever available, the links go to free, full-text articles. Otherwise, they are merely the most recent articles concerning the presence or absence of a link between obesity and the named condition. MD

Acute Pancreatitis

Diagnosis and treatment Acute Pancreatitis: Pancreatitis: Merck Manual Home Edition

Acute pancreatitis: a literature review. [Med Sci Monit. 2009] – PubMed Result

Allergic Diseases

Possible link between allergies and childhood obesity Possible Link Between Childhood Obesity And Allergies

Obesity and allergic diseases. [Acta Dermatovenerol Croat. 2008] – PubMed Result

Alzheimer’s Disease

Relationship of Alzheimer’s disease and obesity Obesity Today, Alzheimer’s Disease Tomorrow?

Adiposity, type 2 diabetes, and Alzheimer’s diseas…[J Alzheimers Dis. 2009] – PubMed Result

Adiposity and Alzheimer’s disease. [Curr Alzheimer Res. 2007] – PubMed Result

The epidemiology of adiposity and dementia. [Curr Alzheimer Res. 2007] – PubMed Result

Body mass index in midlife and risk of Alzheimer d…[Curr Alzheimer Res. 2007] – PubMed Result

Central obesity and increased risk of dementia mor…[Neurology. 2008] – PubMed Result

Asthma

Understanding the asthma-obesity connection Wider Waist Boosts Asthma Risk – US News and World Report

Researchers have been trying for years to sort out the relationship between asthma and obesity. Some have found no relationship Does higher body mass index contribute to worse as…[J Allergy Clin Immunol. 2009] – PubMed Result while others have.

Fitness and body weight in asthma Fitness, daily activity and body composition in ch…[Allergy. 2009] – PubMed Result

Asthma and obesity in 4-5 year olds Association between asthma symptoms and obesity in…[J Asthma. 2009] – PubMed Result

Asthma, the metabolic syndrome and obesity Asthma-like symptoms are increased in the metaboli…[J Asthma. 2009] – PubMed Result

Overweight, obesity, and incident asthma: a meta-a…[Am J Respir Crit Care Med. 2007] – PubMed Result

A meta-analysis of the effect of high weight on as…[Arch Dis Child. 2006] – PubMed Result

Obesity and the lung: 1. Epidemiology. [Thorax. 2008] – PubMed Result

On-line self tests for children and adults Nationwide Asthma Screening Program — Self Tests – ACAAI

Atrial Fibrillation

AHRQ: Management of new atrial fibrillation New Report Available on Management of New Onset Atrial Fibrillation

Meta-analysis shows increasing BMI increases AF risk Atrial fibrillation and obesity–results of a meta…[Am Heart J. 2008] – PubMed Result

Epidemiology of atrial fibrillation. [Swiss Med Wkly. 2009] – PubMed Result

Obesity and the risk of new-onset atrial fibrillat…[JAMA. 2004] – PubMed Result

Risk of new-onset atrial fibrillation in relation …[Arch Intern Med. 2006] – PubMed Result

Effect of coffee and obesity on AF Effect of coffee consumption, lifestyle and acute …[J Cardiovasc Med (Hagerstown). 2008] – PubMed Result

Obesity associated with increased left atrial size Body mass index is an independent determinant of l…[Heart Lung Circ. 2008] – PubMed Result

Tests for Atrial Fibrillation Atrial Fibrillation Diagnosis – Mayo Clinic

Attention Deficit Disorder-Hyperactivity

What is the relationship between attention deficit/hyperactivity disorder and obesity? International Journal of Obesity – Abstract of article: Overweight//obesity and attention deficit and hyperactivity disorder tendency among adolescents in China

Association Between Adult Attention Deficit/Hypera…[Obesity (Silver Spring). 2009] – PubMed Result

ADHD associated with long term weight loss Treatment of refractory obesity in severely obese …[Int J Obes (Lond). 2009] – PubMed Result

Attention-deficit/hyperactivity disorder (ADHD) an…[Crit Rev Food Sci Nutr. 2008] – PubMed Result

Symptoms of attention-deficit/hyperactivity disord…[Eat Behav. 2008] – PubMed Result

Barrett’s Esophagus

Exploring the association between elevated body ma…[Ann Thorac Surg. 2009] – PubMed Result

Birth Defects

Overview: http://www.reuters.com/article/scienceNews/idUSTRE51979K20090210

See: JAMA — Maternal Overweight and Obesity and the Risk of Congenital Anomalies: A Systematic Review and Meta-analysis, February 11, 2009, Stothard et al. 301 (6): 636

USPSTS Recommendations on Folic Acid Consumption

Folic acid for the prevention of neural tube defects: U.S. Preventive Services Task Force recommendation statement.

Blood Pressure, Hypertension

How Do I Know If I Have High Blood Pressure?

Visceral obesity associated with lack of success in hypertension treatment Blood pressure control and components of the metab…[Cardiovasc Diabetol. 2009] – PubMed Result

High blood pressure (HBP), blood pressure readings

Questions on long term improvements in blood pressure with weight loss. Long-term weight loss from lifestyle intervention …[Hypertension. 2009] – PubMed Result

Blount Disease

Association with obesity Blount disease. [J Bone Joint Surg Am. 2009] – PubMed Result

Body mass index as a prognostic factor in developm…[J Pediatr Orthop. 2007] – PubMed Result

Relationship to Childhood Obesity Blount disease. [J Bone Joint Surg Am. 2009] – PubMed Result

Breast Cancer

Combined effects of obesity and type 2 diabetes co…[Cardiovasc Diabetol. 2009] – PubMed Result

Adipocytokines and breast cancer risk. [Chin Med J (Engl). 2007] – PubMed Result

Obesity and mammography: a systematic review and m…[J Gen Intern Med. 2009] – PubMed Result

Cancer, General

See Breast Cancer, Endometrial, Esophageal, Ovarian, Pancreatic

Body-mass index and incidence of cancer: a systema…[Lancet. 2008] – PubMed Result

Cancer incidence and mortality in relation to body…[BMJ. 2007] – PubMed Result

Cancer is a preventable disease that requires majo…[Pharm Res. 2008] – PubMed Result

Effectiveness of Behavioral Interventions to Modify Physical Activity Behaviors in General Populations and Cancer Patients and Survivors: Summary, Evidence Report/Technology Assessment No 102

Energy balance, physical activity, and cancer risk. [Methods Mol Biol. 2009] – PubMed Result

Cardiovascular Disease, see also Heart Disease

Fitness and abdominal obesity are independently as…[J Intern Med. 2009] – PubMed Result

Disease Risk Obesity and cardiovascular disease: pathophysiolog…[Circulation. 2006] – PubMed Result

Surgery: Is extreme obesity a risk factor for cardiac surge…[Eur J Cardiothorac Surg. 2006] – PubMed Result

Effect of obesity on early morbidity and mortality…[Heart Lung Circ. 2007] – PubMed Result

Findings from Project HeartBeat! Their importance …[Am J Prev Med. 2009] – PubMed Result

Youth with obesity and type 2 diabetes have heart abnormalities Youth with obesity and obesity-related type 2 diab…[Circulation. 2009] – PubMed Result

Use of BMI or other indicators Waist-height ratio as a predictor of coronary hear…[Epidemiology. 2009] – PubMed Result

Cataracts

Central Obesity and the metabolic syndrome appear to raise the risks of cataracts Relation between cataract and metabolic syndrome a…[Eur J Ophthalmol. 2007 Jul-Aug] – PubMed Result

Cholesterol, Hypercholesterolemia

NHLBI, High Blood Cholesterol: What You Need to Know

Increased body mass and depressive symptomatology …[Lipids Health Dis. 2009] – PubMed Result

Chronic Diseases

Best Practices for reducing obesity and chronic disease

Reducing obesity and related chronic disease risk …[Obes Rev. 2006] – PubMed Result

Colorectal Cancer

Obesity and colon and rectal cancer risk: a meta-a…[Am J Clin Nutr. 2007] – PubMed Result

Obesity and risk of colorectal cancer: a meta-anal…[Cancer Epidemiol Biomarkers Prev. 2007] – PubMed Result

Obesity and colorectal cancer risk: a meta-analysi…[World J Gastroenterol. 2007] – PubMed Result

Obesity and risk of colorectal cancer: a meta-anal…[Cancer Epidemiol Biomarkers Prev. 2007] – PubMed Result

Deep Vein Thrombosis

The Coalition to Prevent DVT has a risk assessment tool at Assess Your DVT Bloood Clot Risks

[Influence of body mass index and age on deep vein…[Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2006] – PubMed Result

Cardiovascular evaluation and management of severe…[Circulation. 2009] – PubMed Result

Metabolic syndrome and risk of venous thromboembol…[J Thromb Haemost. 2009] – PubMed Result

Greater fish, fruit, and vegetable intakes are rel…[Circulation. 2007] – PubMed Result

Depression

The relationship between abdominal fat, obesity, a…[J Psychosom Res. 2009] – PubMed Result

Altered executive function in obesity. Exploration…[Appetite. 2009] – PubMed Result

A prospective study of the role of depression in t…[Pediatrics. 2002] – PubMed Result

Depression and body mass index, a u-shaped associa…[BMC Public Health. 2009] – PubMed Result

Psychosocial aspects of obesity. [Adv Psychosom Med. 2006] – PubMed Result

Diverticulitis

AHRQ: Research Activities, July 2009: Chronic Disease: Obesity boosts risk of diverticulitis and diverticular bleeding

Research Activities, July 2009: Chronic Disease: Obesity boosts risk of diverticulitis and diverticular bleeding

Obesity increases the risks of diverticulitis and …[Gastroenterology. 2009] – PubMed Result

Drug Induced Weight Gain

Epidemiology, implications and mechanisms underlyi…[J Psychiatr Res. 2003 May-Jun] – PubMed Result

[Psychotropic drugs induced weight gain: a review …[Encephale. 2005 Jul-Aug] – PubMed Result

Preventive treatment of migraine: effect on weight. [Curr Pain Headache Rep. 2008] – PubMed Result

AHRQ Effective Health Care Program – Summary Guides

Weight issues for people with epilepsy–a review. [Epilepsia. 2007] – PubMed Result

Weight gain in the treatment of mood disorders. [J Clin Psychiatry. 2003] – PubMed Result

Weight gain in bipolar disorder: pharmacological t…[Acta Psychiatr Scand. 2008] – PubMed Result

Bipolar disorder, obesity, and pharmacotherapy-ass…[J Clin Psychiatry. 2003] – PubMed Result

Endometrial Cancer

Endometrial Cancer Risk Among Younger, Overweight …[Obstet Gynecol. 2009] – PubMed Result

New review on obesity and endometrial cancer Body size, adult BMI gain and endometrial cancer r…[Int J Cancer. 2009] – PubMed Result

Epilepsy

Obesity related to undiagnosed epilepsy in children Obesity is a common comorbidity for pediatric pati…[Neurology. 2009] – PubMed Result

Erectile Dysfunction

The triad of erectile dysfunction, hypogonadism and the metabolic syndrome

Beneficial impact of exercise and obesity interven…[J Sex Med. 2009] – PubMed Result

Effect of lifestyle changes on erectile dysfunctio…[JAMA. 2004] – PubMed Result

Esophageal Cancer

Body mass index and adenocarcinomas of the esophag…[Cancer Epidemiol Biomarkers Prev. 2006] – PubMed Result

Abdominal Obesity Abdominal obesity and the risk of esophageal and g…[Cancer Epidemiol Biomarkers Prev. 2008] – PubMed Result

Fecal Incontinence

Fecal incontinence in obese women with urinary inc…[Am J Obstet Gynecol. 2009] – PubMed Result

Gallstone Disease

[Gallbladder disease and obesity] [Gac Med Mex. 2004 Jul-Aug] – PubMed Result

Gallstone disease: Primary and secondary preventio…[Best Pract Res Clin Gastroenterol. 2006] – PubMed Result

GERD (Gastroesophageal reflux disease)

Relationship of BMI to GERD in the US Body mass index and gastroesophageal reflux diseas…[Am J Gastroenterol. 2006] – PubMed Result

Meta-analysis: obesity and the risk for gastroesop…[Ann Intern Med. 2005] – PubMed Result

AHRQ Effective Health Care Program – Summary Guides

New Guidelines American Gastroenterological Association medical position statement on the management of gastroesophageal reflux disease

Gestational Diabetes

Intrauterine exposure to gestational diabetes, chi…[Am J Hypertens. 2009] – PubMed Result

Obese Mothers at risk for Gestational Diabetes. See: Maternal obesity and risk of gestational diabetes mellitus: A meta-analysis — Chu et al., 10.2337/dc06-2559a — Diabetes Care

Maternal obesity and risk of gestational diabetes …[Diabetes Care. 2007] – PubMed Result

AHRQ Clinician’s Guide http://effectivehealthcare.ahrq.gov/repFiles/2009_0804GDM_Clinician_final.pdf

Gum Disease

Obesity is associated with gum disease with inflammation being a common possible method of action Obesity Boosts Gum Disease Risk – Forbes.com

Heart Disease

The obesity paradox: body mass index and outcomes …[Arch Intern Med. 2005] – PubMed Result

Optimal Body Weight for the Prevention of Coronary…[Obesity (Silver Spring). 2009] – PubMed Result

Childhood obesity, CVD risk Childhood obesity and adult cardiovascular disease…[Int J Obes (Lond). 2009] – PubMed Result

Different degrees of overweight: anthropometric in…[Acta Cardiol. 2009] – PubMed Result

Optimal Body Weight for the Prevention of Coronary…[Obesity (Silver Spring). 2009] – PubMed Result

Impact of obesity on cardiovascular disease. [Endocrinol Metab Clin North Am. 2008] – PubMed Result

Obesity and cardiovascular disease: risk factor, p…[J Am Coll Cardiol. 2009] – PubMed Result

The joint effects of physical activity and body ma…[Arch Intern Med. 2008] – PubMed Result

Body mass index and vigorous physical activity and…[Circulation. 2009] – PubMed Result

Association of overweight with increased risk of c…[Arch Intern Med. 2007] – PubMed Result

Obesity and disease management: effects of weight …[Obes Res. 2001] – PubMed Result

Inflammation

Small study: Anti-inflammatory treatments (aspirin, statins) may help with weight loss in patients with type 2 diabetes. The effect of anti-inflammatory (aspirin and/or st…[Diabet Med. 2009] – PubMed Result

Obesity and the role of adipose tissue in inflammation and metabolism — Greenberg and Obin 83 (2): 461S — American Journal of Clinical Nutrition

Obesity, innate immunity and gut inflammation. [Curr Opin Gastroenterol. 2007] – PubMed Result

The evolving role of inflammation in obesity and t…[Curr Diab Rep. 2005] – PubMed Result

Epidemic inflammation: pondering obesity. [Mol Med. 2008 Jul-Aug] – PubMed Result

Relationship between inflammation, insulin resista…[Curr Diabetes Rev. 2006] – PubMed Result

Insulin Resistance

From chronic overnutrition to insulin resistance: …[Nutr Metab Cardiovasc Dis. 2009] – PubMed Result

Permanent impairment of insulin resistance from pr…[Med Hypotheses. 2009] – PubMed Result

Kidney Disease

Should prevention of chronic kidney disease start …[Int Urol Nephrol. 2008] – PubMed Result

Overweight, obesity and chronic kidney disease. [Nephron Clin Pract. 2009] – PubMed Result

Waist-to-hip ratio, body mass index, and subsequen…[Am J Kidney Dis. 2008] – PubMed Result

Overweight, obesity, and the development of stage …[Am J Kidney Dis. 2008] – PubMed Result

Association between obesity and kidney disease: a …[Kidney Int. 2008] – PubMed Result

Lipids, Hyperlipidemia

Bridging science and health policy in cardiovascul…[Atheroscler Suppl. 2009] – PubMed Result

Genetic influence of lipids HDL subspecies in young adult twins: heritability …[Obesity (Silver Spring). 2009] – PubMed Result

Macrosomia

The influence of obesity and diabetes on the preva…[Am J Obstet Gynecol. 2004] – PubMed Result

Macular Degeneration

Changes in waist-hip and macular degeneration Changes in abdominal obesity and age-related macul…[Arch Ophthalmol. 2008] – PubMed Result

Obesity and eye diseases. [Surv Ophthalmol. 2007 Mar-Apr] – PubMed Result

Melonoma Cancer

Cutaneous melanoma and obesity in the Agricultural…[Ann Epidemiol. 2008] – PubMed Result

Metabolic Syndrome

Abdominal obesity and the metabolic syndrome: cont…[Arterioscler Thromb Vasc Biol. 2008] – PubMed Result

The concept of cardiometabolic risk: Bridging the …[Ann Med. 2008] – PubMed Result

Is visceral obesity the cause of the metabolic syn…[Ann Med. 2006] – PubMed Result

Maternal obesity, gestational diabetes and large for gestational age factors Metabolic syndrome in childhood: association with …[Pediatrics. 2005] – PubMed Result

Lifestyle intervention in obese children with non-…[Arch Dis Child. 2009] – PubMed Result

Migraines

Obesity may raise migraine risk, U.S. study finds | Science & Health | Reuters

Obesity, migraine, and chronic migraine: possible …[Neurology. 2007] – PubMed Result

Body mass index and headaches: findings from a nat…[Cephalalgia. 2008] – PubMed Result

Migraines and the metabolic syndrome Migraine in metabolic syndrome. [Neurologist. 2009] – PubMed Result

Mobility Problems in the Elderly

Metabolic syndrome and physical decline in older p…[J Gerontol A Biol Sci Med Sci. 2009] – PubMed Result

Lifestyle factors and incident mobility limitation…[Obesity (Silver Spring). 2007] – PubMed Result

Musculoskeletal Disorders

Musculoskeletal disorders associated with obesity:…[Obes Rev. 2006] – PubMed Result

Musculoskeletal effects of obesity. [Curr Opin Pediatr. 2009] – PubMed Result

Musculoskeletal findings in obese subjects before …[Int J Obes (Lond). 2007] – PubMed Result

Nonalcoholic Fatty Liver Disease

NAFLD strongly affects Hispanic population through obesity and insulin resistance Correlates and heritability of nonalcoholic fatty …[Obesity (Silver Spring). 2009] – PubMed Result

Metabolic liver disease of obesity and role of adi…[World J Gastroenterol. 2007] – PubMed Result

Metabolic syndrome and non-alcoholic fatty liver d…[Ann Hepatol. 2009] – PubMed Result

NASH

Nonalcoholic Steatohepatitis

Role of inflammation in nonalcoholic steatohepatit…[Curr Opin Gastroenterol. 2005] – PubMed Result

Obesity Genetic Syndromes

Genetic obesity syndromes. [Front Horm Res. 2008] – PubMed Result

Genetic and hereditary aspects of childhood obesit…[Best Pract Res Clin Endocrinol Metab. 2005] – PubMed Result

OB/GYN Issues; see also Birth Defects

Greater cesarean deliveries in overweight/obese women Maternal obesity and risk of cesarean delivery: a …[Obes Rev. 2007] – PubMed Result

Higher risk of stillbirths Maternal obesity and risk of stillbirth: a metaana…[Am J Obstet Gynecol. 2007] – PubMed Result

The impact of maternal obesity on maternal and fet…[Rev Obstet Gynecol. 2008] – PubMed Result

Higher risks of neural tube defects Maternal obesity and risk of neural tube defects: …[Am J Obstet Gynecol. 2008] – PubMed Result

Greater maternal weight and the ongoing risk of ne…[Obstet Gynecol. 2005] – PubMed Result

Reproductive results after bariatric surgery Reproductive outcome after bariatric surgery: a cr…[Hum Reprod Update. 2009 Mar-Apr] – PubMed Result

Pregnancy and fertility following bariatric surger…[JAMA. 2008] – PubMed Result

Obstetric outcome following laparoscopic adjustabl…[Int J Gynaecol Obstet. 2007] – PubMed Result

Osteoarthritis

Osteoarthritis of the knee and hip and activity: a…[Joint Bone Spine. 2006] – PubMed Result

Obesity and osteoarthritis in knee, hip and/or han…[BMC Musculoskelet Disord. 2008] – PubMed Result

Obesity increases the likelihood of total joint re…[Int Orthop. 2007] – PubMed Result

The relationship between obesity and the age at wh…[J Bone Joint Surg Br. 2008] – PubMed Result

Ovarian Cancer

Height, body mass index, and ovarian cancer: a poo…[Cancer Epidemiol Biomarkers Prev. 2008] – PubMed Result

Body mass index, height, and the risk of ovarian c…[Cancer Epidemiol Biomarkers Prev. 2002] – PubMed Result

Pain

Health-related quality of life in obese persons se…[J Fam Pract. 1996] – PubMed Result

Overview of the relationship between pain and obes…[J Rehabil Res Dev. 2007] – PubMed Result

low back pain and obesity – PubMed Results

Pancreatic Cancer

Body mass index and risk, age of onset, and surviv…[JAMA. 2009] – PubMed Result

Pelvic Floor Disorders

Obesity is associated with increased prevalence an…[Surg Obes Relat Dis. 2008] – PubMed Result

Obesity and pelvic floor disorders: a systematic r…[Obstet Gynecol. 2008] – PubMed Result

PCOS (Polycystic Ovarian Syndrome)

Effect of body weight on PCOS Effect of body mass index on clinical manifestatio…[Int J Gynaecol Obstet. 2009] – PubMed Result

Polycystic ovary syndrome: a major unrecognized ca…[Rev Cardiovasc Med. 2009] – PubMed Result

Pregnancy Outcomes

Obesity as an independent risk factor for elective…[Obes Rev. 2009] – PubMed Result

Effect of Body Mass Index on pregnancy outcomes in…[BMC Public Health. 2007] – PubMed Result

Prostate Cancer

Obese men have larger tumors Obese men have higher-grade and larger tumors: an …[Prostate Cancer Prostatic Dis. 2009] – PubMed Result

Psoriasis

Psoriasis and the metabolic syndrome. [J Drugs Dermatol. 2008] – PubMed Result

Pseudo Tumor cerebri (idiopathic intercranial hypertension)

Profiles of obesity, weight gain, and quality of l…[Am J Ophthalmol. 2007] – PubMed Result

Gastric surgery for pseudotumor cerebri associated…[Ann Surg. 1999] – PubMed Result

Idiopathic intracranial hypertension: the associat…[BMC Ophthalmol. 2007] – PubMed Result

Renal Transplantation

Severe obesity affects success of renal transplantation Effect of degree of obesity on renal transplant ou…[Transplant Proc. 2008] – PubMed Result

Morbid Obesity not a contraindication to transplant Morbid obesity is not a contraindication to kidney…[Am J Surg. 2004] – PubMed Result

Severe Mental Illness

Obesity in patients with severe mental illness Overview of managing medical comorbidities in pati…[J Clin Psychiatry. 2009] – PubMed Result

Sexual Dysfunction

International Journal of Impotence Research – Abstract of article: Obesity and sexual dysfunction, male and female

Male obesity and alteration in sperm parameters. [Fertil Steril. 2008] – PubMed Result

Sleep Apnea

Is there a connection with obesity? Is there a clear link between overweight/obesity a…[Sleep Med Rev. 2008] – PubMed Result

Sleep Apnea Medicare announces new coverage MEDICARE ANNOUNCES FINAL COVERAGE POLICY FOR SLEEP TESTING FOR THE DIAGNOSIS OF OBSTRUCTIVE SLEEP APNEA

Stroke

Contribution of obesity and abdominal fat mass to …[Stroke. 2008] – PubMed Result

The Impact of Body Mass Index on Mortality After S…[Stroke. 2009] – PubMed Result

AHRQ Stroke Prevention Recommendations

Healthy lifestyle and the risk of stroke in women. [Arch Intern Med. 2006] – PubMed Result

Lifestyle and stroke risk: a review. [Curr Opin Neurol. 2009] – PubMed Result

Obesity: effects on cardiovascular disease and its…[J Am Board Fam Med. 2008 Nov-Dec] – PubMed Result

Swine Flu

Swine Flu may be especially virulent in persons with morbid obesity Intensive-care patients with severe novel influenz…[MMWR Morb Mortal Wkly Rep. 2009] – PubMed Result

Type 1 Diabetes

Children with type 1 diabetes likely to be overweight Atlanta health, diet and fitness news | ajc.com

Childhood BMI, breastfeeding and risk of type 1 diabetes Childhood body mass index (BMI), breastfeeding and…[Diabet Med. 2008] – PubMed Result

Type 2 Diabetes

Obesity and Type 2 diabetes: global phenomenon IDF Diabetes Atlas – Obesity and type 2 diabetes

CDC Data & Statistics | Feature: Diabetes is Common, Disabling, Deadly, and On the Rise

CDC’s Diabetes Program – Publications & Products – National Diabetes Fact Sheet 2005

Primer on Diabetes San Fernando Valley Sun – A Diabetes Primer

Prevalence of diabetes among children, adolescents Prevalence of overweight and obesity in youth with…[Pediatr Diabetes. 2009] – PubMed Result

AHRQ Effective Health Care Program – Summary Guides

Effect of weight loss on diabetes Influences of weight loss on long-term diabetes ou…[Proc Nutr Soc. 2008] – PubMed Result

Benefits of weight loss for type 2 diabetics Impact of a weight management program on health-re…[Arch Intern Med. 2009] – PubMed Result

No definitive studies of best dietary practices Dietary advice for the prevention of type 2 diabet…[Cochrane Database Syst Rev. 2008] – PubMed Result

Not much evidence that physical activity and dietary interventions prevent type 2 diabetes Exercise or exercise and diet for preventing type …[Cochrane Database Syst Rev. 2008] – PubMed Result

United Kingdom’s National Institute for Clinical Evidence (NICE) issues new guidelines for treating type 2 diabetes. Type 2 Diabetes – newer agents (partial update of CG66)

Studies confirm effectiveness of bariatric surgery in resolving diabetes Data confirm long-term effects of bariatric surgery on type 2 diabetes

UK Diabetes drug may also cause weight loss Diabetes Drug: New Treatment Helps Lower Blood Pressure And Weight Loss | Health | Sky News

FDA to review once a week diabetes drug US FDA To Review Once-A-Week Diabetes Drug Exenatide – WSJ.com

Stopping type 2 diabetes in children Experts: Most type 2 diabetes can be stopped in childhood – USATODAY.com

Urinary Incontinence

Weight loss helps women with urinary incontinence Weight Loss in Overweight and Obese Women Reduces Urinary Incontinence, January 28, 2009 News Release – National Institutes of Health (NIH)

A systematic review of overweight and obesity as r…[Neurourol Urodyn. 2008] – PubMed Result

Weight loss to treat urinary incontinence in overw…[N Engl J Med. 2009] – PubMed Result

Uterine Cancer

Obesity positively associated with uterine cancer The impact of BMI on subgroups of uterine cancer. [Br J Cancer. 2009] – PubMed Result