Posts Tagged ‘National Institutes of Health’

NIH Recommends A1c Testing

January 26th, 2012

The National Institutes of Health has come out for expanded A1c testing. Their press release and fact sheet point out that the A1c test does not require fasting and helps identify diabetes and pre-diabetes. They recommend testing of anyone 45 years old or younger than 45 are overweight, inactive or have at least one risk factor for type 2 diabetes. New NIH fact sheet explains test for diabetes, prediabetes, January 26, 2012 News Release – National Institutes of Health (NIH)

Below the Radar

December 23rd, 2011

Before leaving for his holiday in Hawaii, President Barack Obama signed the appropriations bill to keep the government running. Included in the bill is a provision establishing the National Center for Advancing Translational Sciences (NCATS). This center is the brainchild of NIH Director Francis Collins. Statement by NIH Director Dr. Francis Collins – NIH Launches National Center for Advancing Translational Sciences, December 23, 2011 – The NIH Director – National Institutes of Health (NIH) It is intended to develop resources at NIH to facilitate moving basic biomedical research into treatments and removing roadblocks to incorporating new findings into patient care. Off the record, NIH officials are concerned that one of the bigger roadblocks is the failure of new drugs to gain approval by the Food and Drug Administration. Obviously, this includes drugs to treat obesity. While addressing this specific issue is not part of the NCATS mission, it clearly provides a platform to move in this direction. The very first activity of this center is a collaboration with FDA and DARPA to develop a chip to screen new drugs for toxicity. NIH, DARPA and FDA collaborate to develop cutting-edge technologies to predict drug safety, September 16, 2011 News Release – National Institutes of Health (NIH)

As it happens, my paper on the FDA approval process, written with colleagues,] Christopher Still and Arya Sharma, specifically called for a NIH-FDA-industry-patient group collaboration to find ways to overcome obstacles to the approval of drugs to treat obesity. What’s Up with the FDA – Part 5 | The Downey Obesity Report

So, keep an eye on NCATS. It may become very important and relevant to advancing the treatment of obesity. Proposed NCATS « Feedback NIH

NIH Disses Physical Activity as Cure of Childhood Obesity

November 23rd, 2011

The National Heart, Lung and Blood Institute has issued guidelines endorsed by the American Academy of Pediatrics. They are directed to all primary pediatric care providers to address the known risk factors of cardiovascular disease, including obesity, blood pressure, cholesterol, tobacco and lipids.

The report notes that longitudinal data on non-white populations are lacking and that “Clinically important differences in prevalence of risk factors exist according to race and gender, particularly with regard to tobacco-use rates, obesity prevalence, hypertension, and dyslipidemia.”

The report notes, “Obesity tracks more strongly than any other risk factor, among many reports from studies that have demonstrated this fact…Tracking data on physical data is more limited.”

Regarding overweight and obesity, the report states,

“The dramatic increases in childhood overweight and obesity in the United States since 1980 are an important public health focus. Despite efforts over the last decade to prevent and control obesity, recent reports from the National Health and Nutrition Examination Survey show sustained high prevalence: 17% of children and adolescents have a BMI at the >95th percentile for age and gender. The presence of obesity in childhood in childhood and adolescence is associated with increased evidence of atherosclerosis at autopsy and of subclinical measures of atherosclerosis on vascular imaging. Because of its strong association with many of the other established risk factors for cardiovascular disease, obesity is even more powerfully correlated with atherosclerosis; this association has been shown for BP, dyslipidemia, and insulin resistance in each of the major pediatric epidemiologic studies. Of all of the risk factors, obesity tracks most strongly from childhood into adult life.”

Given that physical activity is a primary prescription for preventing childhood and adolescent obesity, it is interesting to read what the expert panel has to say about its utility:

“A moderate number of RCTs (randomized controlled clinical trials) have evaluated the effect of interventions that addressed only physical activity and/or sedentary behavior on prevention of overweight and obesity. In a small number of these studies, the intervention was effective. It should be noted that these successful interventions often addressed reduction in sedentary behavior rather than attempts to increase physical activity. In a majority of these studies there was no significant difference in body-size measures. Sample sizes were often small and follow-up was often short (frequently < 6 months). ..Overall, the expert panel concluded that on the basis of the evidence review, increasing activity in isolation is of little benefit in preventing obesity. By contrast, the review suggests that reducing sedentary behavior might be beneficial in preventing the development of obesity.”

The report identifies populations at special risk for obesity: children with a BMI between the 85 and 95th percentiles;children in whom there is a positive family history of obesity in 1 or both parents; early onset of increasing weight; excessive weight gain during adolescence; children who have been very active and become inactive. See Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents- NHLBI, NIH

Chance to influence NIH and FDA plans

October 2nd, 2010

The National Institutes of Health (NIH) has opened its Draft Strategic Plan for Obesity Research for public comment. You can review the draft plan and offer comments, but only up to October 14, 2010. See Strategic Plan for NIH Obesity Research 

Also, the Food and Drug Administration has issued its draft strategic plan for 2011-2015. Go to http://www.fda.gov/downloads/AboutFDA/ReportsManualsForms/Reports/StrategicActionPlan/UCM226907.pdf