Posts Tagged ‘obesity’

The Causes of Obesity: There’s more than you think

September 30th, 2010

September 30, 2010

Perhaps the greatest gap between science and policy-making is the understanding of the causes of obesity. For most of the public and policy-makers, it is beyond discussion that obesity is caused by poor diets and lack of physical activity. Scientists, on the other hand, know that, without diminishing the roles diet and exercise play, they are not the whole story.  Obesity is far more complex. This gap has significant implications. Billions of dollars have been spent on strategies which, to be kind, are simplistic. Not only is this wasteful, it distracts or delays our understanding and the development of more effective remedies. Probably no better description, in great detail, of the ‘putative’ causes of obesity is contained in this article by McAllister and a prestigious group of co-authors. Ten putative contributors to the obesity epidemic. [Crit Rev Food Sci Nutr. 2009] – PubMed result. Even if the article is a bit dense, it is worth it to make us all more humble in approaching this disease.

Obesity Researchers Snag Lasker Prize

September 21st, 2010

September 21, 2010                                                                                                                                

One of the most prestigious awards in medicine has gone to two obesity researchers, Douglas Coleman and Jeffrey Friedman, for their work in discovering the hormone leptin. The discovery of leptin transformed obesity research and this prize recognizes that accomplishment. Congratulations! The Lasker Foundation – 2010 Awards

Are you free at noon?

September 21st, 2010

If you are free around noon today, join my live chat on obesity at the Washington Post web site, http://live.washingtonpost.com/obesity-treatment-and-health-care-reform-.html

Insurance Coverage for Intensive Behavioral Counseling

September 21st, 2010

September 21, 2010

RE: Interim Final Rules for Groups Health Plans and Health Insurance Issuers Relating to Coverage of Preventive Services under the Patient Protection and Affordable Care Act, FR 75:41726, July 19, 2010 I would like to express support for the inclusions of coverage of preventive services, particularly that relating to obesity, for group health plans and health insurance issuers. Specifically, the interim final regulations incorporate the level B recommendation of the United States Preventive Services Task Force requiring intensive behavioral counseling of adults for obesity. The background information makes clear that coverage of obesity prevention and reduction services can have extremely positive effects both for individuals and the country as a whole. The background information finds that even modest weight loss produces meaningful improvements in health and reductions in health care spending. The USPSTF recommended high intensity counseling and found insufficient evidence for low or moderate counseling. Their recommendation states, It is advisable to refer obese patients to programs that offer intensive counseling and behavioral interventions for optimal weight loss. The USPSTF defined intensity of counseling by the frequency of the intervention. A high-intensity intervention is more than 1 person-to-person (individual or group) session per month for at least the first 3 months of the intervention. A medium-intensity intervention is a monthly intervention, and anything less frequent is a low-intensity intervention. There are limited data on the best place for these interventions to occur and on the composition of the multidisciplinary team that should deliver high-intensity interventions This is the only specification of the minimum level of frequency, intensity and duration of services. The Overview Section of the regulations state that ?These interim final regulations provide that if a recommendation or guideline for a recommended preventive service does not specify the frequency, method, treatment or setting for the provision of that service, the plan or issuer can use reasonable medical management techniques to determine any coverage limitations.? (At p.41828) Unfortunately, there is not an optimum medical management paradigm for the diverse population which will be covered by this recommendation. This may mean that many health plans will not have guidance on the level of frequency, intensity or duration of behavioral counseling adequate to meet the requirement for ?intensive? and not moderate levels of counseling. The National Institutes of Health funded multicenter clinical trial, LOOK AHEAD, is in the process of identifying optimal intensity and duration of treatment. Their research protocol provides: For the first 6 months, one individual and three group session per month with a recommendation to replace two meals and one snack a day wit liquid shakes and meal bars For months 7-12, one individual and two group meetings per month and continue meal replacements Starting at month 7, more intensive behavioral interventions as well as weight loss medications Year 2-4, treatment on a monthly basis, including at least one on-site visit per month and a second contact by phone, email or mail. Short term-refresher groups and motivational campaigns are also offered three times yearly. After year 4, participants are offered monthly individual visits, as well as one refresher group and one campaign a year. (see The Look AHEAD Study: a Description of the Lifestyle Intervention and the Evidence Supporting it, Obesity 2006 May;14(5):737-752) This ongoing trial is producing significant reductions in weigh loss and associated lipid and cardiovascular risk factors. (Waddent TA, et al, One Year Weight Losses in the Look AHEAD Study: Factors Associated with Success, Obesity (2009)17:713-722) The final regulations direct group health plans and health insurance issurers to the ongoing results of the Look AHEAD trial to identify the optimal level of frequency, intensity and duration of intensive behavioral counseling. In the alternative, the USPSTF could be charged with updating their recommendation based on current clinical studies. Thank you for this opportunity to comment.

War on the Obese – The Ohio Front

September 11th, 2010

In 2003, a prestigious  researcher, Jeffrey M. Friedman, called for a ‘War on Obesity, not the Obese.” A war on obesity, not the obese. [Science. 2003] – PubMed Result We seem, six years later, not able to make the distinction.

Elsewhere we have addressed various attacks on persons with obesity, rather than obesity itself. Medical experts, it seems, appear particularly unable to tell what is a war on obesity and what is a war on persons with obesity.

A ‘War on Obesity’ includes the same elements that have guided other, successful, approaches to health care problems, whether infectious diseases or chronic conditions. The elements are straight-forward: (1) educate the public and health professionals, (2) focus research on finding both the causes and effective interventions, (3) promote prevention, when possible, (4) intervene and treat those affected, (5) if relevant, strongly combat stigmatization and discrimination, as they are impediments to effectively treating and preventing the disease, and (6) consumer protection to stop the exploitation of worried people and their diversion into unproductive avenues of recourse. With obesity, in general, the federal government has only focused on educating the public and promoting prevention (although we still lack proven prevention strategies). All the other strategies have been not totally, but largely, neglected.

Identifying a “War on the Obese” requires a little work. It requires work because stigmatizing overweight/obese people is so ingrained in our culture. It starts early and does not stop. Shunning, embarrassing, ridiculing and penalizing persons with obesity is so ingrained in our society, we take it for granted. How do we recognize it?

Lets take Dr. Toby Cosgrove, CEO of the Cleveland Clinic, statements about hiring obese persons.

1.       On August 12, 2009, David Leonhardt of the New York Times, wrote, “Cosgrove says if it were up to him, if there weren’t legal issues, he would not only stop hiring smokers. He would also stop hiring obese people. When he mentioned this to me during a recent conversation, I told him many people might consider it unfair. He was unapologetic.”

2.       On September 6, 2009, Dr. Cosgrove was interviewed by Guy Raz on NPR:

RAZ: And you have argued that you would not hire people who are obese. Is that fair?

Dr. COSGROVE: No, I think that that was a quote that was taken out of an hour-and-a-half interview. And what I said was that we are concerned about the obesity problem, not about people who are obese.

3.       September 9, 2009, Cleveland .com carried the story, “Clinics Dr. Delos ‘Toby’ Cosgrove defends remarks about not wanting to hire obese people.” Asked at an obesity summit at the Cleveland Clinic, organized by the clinic’s bariatric surgery program by Walt Lindstrom, founder of the Obesity Law and Advocacy Center in California, if he wished ‘he hadn’t said it.” The Dr. Cosgrove demurred and said his comment was meant “to stimulate discussion on the growing costs of obesity.” He said, “I think a lot of people misunderstood what the point was…I never considered not hiring obese people, but I think we have to do something bold to address the problem.” The article goes on, “Cosgrove opened his remarks at the Obesity Summit by highlighting the Clinics health and wellness initiatives. On the obesity front, the hospital has eliminated fried foods, removed soda and candy from vending machines and subsidized Weight Watchers and fitness programs for its 40,000 employees, he said. “In nine months, we’ve lost 110,000 pounds across the organization, which I think is an amazing tribute to the program.”

4.       September 12, 2009: On a Wall St. Journal Health Blog, Dr. Cosgrove said, “it would be illegal to apply a similar standard (not hiring smokers) to people who are obese, because they’re protected by the Americans with Disabilities Act (ADA). He said, “I can’t decide that I’m not going to hire somebody because they are 400 pounds. We don’t hire smokers and that’s perfectly legal.” According to the blog entry, “Cosgrove questioned that rule, suggesting it could hinder efforts to lower the nation’s obesity rate. Dr. Cosgrove said, “We are protecting people who are overweight rather then giving people a social stigma.”  The blog reports that the Department of Justice said that only morbid obesity can be protected by the ADA but only “if it substantially limits a major life activity in the past or is regarded as substantially limiting.”

5.       On September 13, 2009, Connie Schultz, a Cleveland Plain-Dealer Pulitzer-prize winning columnist for her focus on blue-collar families and economics, wrote, “Apparently, it is now fashionable to bash the obese. For the sake of health care, you understand. Nothing personal.” Quoting Dr. Cosgrove remorse that “We are protecting people who are overweight rather than giving people a social stigma” Schultz states, “What, Oh, he must mean all those obese people bragging about the compliments from strangers, the big, welcoming grins on the faces of fellow airline passengers. Not to mention the parade of size-20 models on fashion runways. Yup, obesity is really popular in America. Who wouldn’t want to be called fat. Punishing obesity compounds the problem.”

6.       September 14, 2009, Dr. Cosgrove apologized to employees of the Cleveland Clinic for any “hurtful” comments, stating, “My objective was to spark discussion about premature causes of death, but some of my comments were hurtful to our community. That was certainly not my intent, and for that I apologize.”     

In Cleveland, 70% of adults are over their recommended weight. Obesity is more prevalent among women than men, greater among black adults and higher among older persons than younger ones as well as more prevalent among lower income persons.

The picture of obese persons in Cleveland is intriguing. According to the Center for Health Promotion Research, “Obese and non-obese Clevelanders did not differ in the reporting of adequate fruit and vegetable consumption.” The difference appears to be in physical activity with obese persons reporting less adequate moderate or vigorous physical activity. More than half of all Clevelanders reported not getting adequate weekly amounts of moderate physical activity. BUT, as the report notes, “Clevelanders who were obese were more than twice as likely to report having diabetes (17% vs. 7%) and nearly twice as likely to report having asthma (15% to 8%).”  They also report more hypertension and high cholesterol that non-obese Clevelanders. Therefore, the reports notes, lower levels of physical activity were related to diabetes, hypertension, high cholesterol and heart attacks.

The report goes on to note that obese Clevelanders reported more use of nutrition classes and organized health promotion activities compared to non-obese residents. Fully 75% of obese Clevelanders are trying to lose weight. Of the 76% of Clevelanders who reported seeing a doctor in the past 12 months, only 16% were given advice about their weight! Obese Clevelanders reported using both diet and exercise compared to those who were not obese. And more obese persons used a diet- only approach, “a possible reflection of the mobility issues related to obesity, and the additional need for diet modification.” http://www.case.edu/affil/healthpromotion/Publications/Publications/Steps%20BRFSS%20Data%20Brief%20OBESITY%203.27.08%20FINAL.pdf

Dr. Cosgrove has apologized to his current employees saying he only wanted to talk about premature deaths due to obesity. If he is concerned about premature deaths due to obesity, he might address why does his health plan for employees cover bariatric surgery after a two year waiting period (http://www.clevelandclinic.org/healthplan/plan-cchs-caremanagement.htm#MedBenefitsCoverClarification), one of the longest in the country, and, for which, there is no medical justification?

Even though Dr. Cosgrove has apologized to his employees, does anyone in the hiring process at Cleveland Clinic not understand the boss doesn’t want to see so many fat people on staff? Would you hire an obese Clevelander and take them to meet the boss for the ‘Welcome aboard’ gesture? Not likely.

At the end of the day, there is no evidence that stigmatizing obese persons reverses or resolves the problem. Stigma and discrimination does not work and only increases the sum of human unhappiness. We need new therapies and we need physicians who want to help their patients, and, Dr. Cosgrove, we need positive leadership.

FDA Panel Nixes Qnexa

July 16th, 2010

July 16, 2010

I spent three days at the FDA Advisory Committee hearings this week. The first two days were devoted to Avandia for type 2 diabetes. The third day consisted of a review of the anti-0besity medication, Qnexa, made by Vivus Inc.

The committee voted to keep Avandia on the market in spite of long term studies, meta-analyses and observational studies all pointing to an increased risk of heart attacks. And this in a field where there are multiple classes of drugs which enhance glucose control. The evidence was there (in my opinion) but the committee stuck with the drug.

On the other hand, in reviewing Qnexa, the evidence was there that it met the FDA’s requirements for approval. What the committee had was higly speculative fear that it might be approving another phen-fen. (Never mind that Qnexa’s two components – phentermine and topirmate – have been used for decades.) Fear trumped evidence when it comes to obesity products.

Most of the audience at the hearing felt stunned when the vote was announced. Most had expected easy approval as the effectiveness data was very clear and the safety issues were well-addressed, small and mainly speculative. Hopefully, the FDA will look at the company’s two year data in September and approve Qnexa.

Is obesity leveling off and what does it matter?

January 23rd, 2010

Ten days ago, the media was touting new reports from the CDC that the obesity epidemic was ‘leveling off’ or  ‘reaching a plateau.’ The news was taken in some quarters with a sense of relief:”Whew, I’m glad that’s over.” Well, don’t get too comfortable. The reports have a lot more to say and overall, this is not a time for complacency.

What the reports actually say.

First, regarding adults, (Prevalence and trends in obesity among US adults, … [JAMA. 2010] – PubMed result), the authors note that the prevalence of obesity is high, exceeding 30% in most age and sex groups except for men 20-39 years old. Strong racial and ethnic differences persist with very high rates among African-American and Hispanic Americans compared to white Americans. Prevalence of severe or morbid obesity, called class 3, (a BMI of 40 or more) was 5.7% overall, with 4.2% for mean and 7.2% for women, including a rate of 14.2% among non-Hispanic black women. What their analyses found was that the earlier rates of increase were on the order of 6 to 7 percentage points. In the this analysis, over the past ten years, the rate of increase is 4.7 percent. Bottom line: rates are still going up.

Second, regarding children, (Prevalence of high body mass index in US children … [JAMA. 2010] – PubMed result) the authors found no statistically significant increases over the last 10 years among girls. Among boys, there is a different picture. Heavy boys between 6 and 19 years of age are getting heavier. Bottom line: the prevalence of obesity has tripled among school-age children and adolescents if you go back to the 1980s. It is high – 17%- and remains high.

So, is the epidemic leveling off? Answer: we don’t know yet. These analyses look at the last ten year trends and they are less than the peak periods of increase. Is this a pause on an upward track or the start of a decline?

Experts I talked with are not too optimistic. First, there is the perennial question of relying on the BMI. A recent paper indicates that more precise tools, like skinfold tests, would have predicted the obesity epidemic by 10-20 years. The timing of the rise in U.S. obesity varies with… [Econ Hum Biol. 2009] – PubMed result. Second, there isn’t a clear explanation of why the rates should be leveling off. We’d like to think people are changing their behavior but the evidence is there is less compliance with recommended dietary and physical activity standards than ever. Adherence to healthy lifestyle habits in US adults… [Am J Med. 2009] – PubMed result  Compliance with the DASH diet among persons with hypertension has slipped. Deteriorating dietary habits among adults with hyp… [Arch Intern Med. 2008] – PubMed result

The recession may be causing people to forgo buying more expensive but healthier foods Recession Weighs on Waistlines – chicagotribune.com. Many clinicians running medical weight management programs I have talked with report their volume is down 20-30%.

Hopefully, this is the beginning of a levelling or downard trend in obesity but we will not know for sure until more information comes in. In the meantime, we should consider that we don’t to be having phenomenal increases in obesity to justify more programs for treatment and prevention. An editorial  by J Michael Graziano on the two reports from CDC, states, “Even if these trends can be maintained, 68% of US adults are overweight or obese, and almost 32% of school-aged US children and adolescents are at or above the 85th percentile of BMI for age. Given the risk of obesity-related major health problems, a massive public health campaign to raise awareness about the effects of overweight and obese is necessary..Major research initiatives are needed to identify better management and treatment options. The longer the delay is taking aggressive action, the higher the likelihood that the significant progress achieved in decreasing chronic disease rates during the last 40 years will be negated, possibly even with a decrease in life expectancy.”  Amen.

Are we looking for answers in the wrong places?

January 23rd, 2010

In a cross-sectional and longitudinal study in Canada, nine known risk factors for overweight and obesity were examined. Only short-sleep duration, low dietary calcium intake and high disinhibited  eating were found to be significantly associated with higher BMI in both men and women. Short sleep duration had a greater effect than parental obesity, television viewing and physical inactivity. Population studies indicate that sleep duration has decreased over recent years. The authors note that affecting obesity by addressing  the traditional risk factors – reduced physical activity, high caloric intake and high fat intake – have not been very successful and that attention to factors which are not caloric per se may be worthwhile.  Risk factors for adult overweight and obesity in t… [Obesity (Silver Spring). 2009] – PubMed result