Posts Tagged ‘pediatric obesity’

Information on dosing of drugs for children with obesity not available

October 9th, 2015

A new study has concluded that only 2 of 25 emergency care drugs for children contained dosing information on the FDA approved label for obese children and adults compared with 22 of 25 for normal weight children. Rowe and colleagues found no sufficient pharmacokinetic data in the literature for any of the emergency care drugs for children with obesity. Obesity is an important component of the appropriate dosing for drugs do to altered body composition and physiologic mechanisms. Another article by Kendrick and colleagues points out the uncertainties in prescribing information for children with obesity. Also, see this article by Oeser and colleagues on the same topic. Roux-en-Y gastric bypass surgery in adults can also affect the pharmacokinetics of drugs but the information, according to a paper by Srinivas, is mixed.