Posts Tagged ‘Type 2 diabetes’

FDA Approves Once Weekly Drug for Diabetes; Shows Weight Loss

January 28th, 2012

The Food and Drug Administration has approved Amylin Pharmaceutical’s Bydureon for thetreatment of type 2 diabetes. This is the first once-weekly treatment for type 2 diabetes. It is hoped that this feature will lead to higher adherence to the treatment regimen, although as with Byetta, it is injectable. The drug is exenatide, a GLP-1 receptor agonist. Study results showed an improvement in glycemic control.  A1C levels, a measure of blood sugar, decreased an average of 1.6 points.

Many patients with Type 2 diabetes are also overweight or obese. Many drugs for type 2 diabetes actually cause weight gain. The advantage of Bydureon (and its daily administered counterpart, Byetta) is that patients taking Bydureon can achieve weight loss, in addition to improvements in glycemia, blood pressure, and cholesterol in both overweight and obesity subjects with and without type 2 diabetes. Effects of glucagon-like peptide-1 receptor agonists on … [BMJ. 2012] – PubMed – NCBI

A very small study of 12 children and adolescents with extreme obesity also showed significant improvements, suggesting the need for a larger study. Exenatide as a weight-loss therapy i… [Obesity (Silver Spring). 2012] – PubMed – NCBI

More information is available at www.BYDUREON.com.

NIH Recommends A1c Testing

January 26th, 2012

The National Institutes of Health has come out for expanded A1c testing. Their press release and fact sheet point out that the A1c test does not require fasting and helps identify diabetes and pre-diabetes. They recommend testing of anyone 45 years old or younger than 45 are overweight, inactive or have at least one risk factor for type 2 diabetes. New NIH fact sheet explains test for diabetes, prediabetes, January 26, 2012 News Release – National Institutes of Health (NIH)

NIH Disses Physical Activity as Cure of Childhood Obesity

November 23rd, 2011

The National Heart, Lung and Blood Institute has issued guidelines endorsed by the American Academy of Pediatrics. They are directed to all primary pediatric care providers to address the known risk factors of cardiovascular disease, including obesity, blood pressure, cholesterol, tobacco and lipids.

The report notes that longitudinal data on non-white populations are lacking and that “Clinically important differences in prevalence of risk factors exist according to race and gender, particularly with regard to tobacco-use rates, obesity prevalence, hypertension, and dyslipidemia.”

The report notes, “Obesity tracks more strongly than any other risk factor, among many reports from studies that have demonstrated this fact…Tracking data on physical data is more limited.”

Regarding overweight and obesity, the report states,

“The dramatic increases in childhood overweight and obesity in the United States since 1980 are an important public health focus. Despite efforts over the last decade to prevent and control obesity, recent reports from the National Health and Nutrition Examination Survey show sustained high prevalence: 17% of children and adolescents have a BMI at the >95th percentile for age and gender. The presence of obesity in childhood in childhood and adolescence is associated with increased evidence of atherosclerosis at autopsy and of subclinical measures of atherosclerosis on vascular imaging. Because of its strong association with many of the other established risk factors for cardiovascular disease, obesity is even more powerfully correlated with atherosclerosis; this association has been shown for BP, dyslipidemia, and insulin resistance in each of the major pediatric epidemiologic studies. Of all of the risk factors, obesity tracks most strongly from childhood into adult life.”

Given that physical activity is a primary prescription for preventing childhood and adolescent obesity, it is interesting to read what the expert panel has to say about its utility:

“A moderate number of RCTs (randomized controlled clinical trials) have evaluated the effect of interventions that addressed only physical activity and/or sedentary behavior on prevention of overweight and obesity. In a small number of these studies, the intervention was effective. It should be noted that these successful interventions often addressed reduction in sedentary behavior rather than attempts to increase physical activity. In a majority of these studies there was no significant difference in body-size measures. Sample sizes were often small and follow-up was often short (frequently < 6 months). ..Overall, the expert panel concluded that on the basis of the evidence review, increasing activity in isolation is of little benefit in preventing obesity. By contrast, the review suggests that reducing sedentary behavior might be beneficial in preventing the development of obesity.”

The report identifies populations at special risk for obesity: children with a BMI between the 85 and 95th percentiles;children in whom there is a positive family history of obesity in 1 or both parents; early onset of increasing weight; excessive weight gain during adolescence; children who have been very active and become inactive. See Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents- NHLBI, NIH

Staggering New Cost Projections for Obesity

November 22nd, 2011

Simulation model predicts increased health care costs and utilization in rising obese populations in the United States and the United Kingdom, predicting 65 million more obese in the US and 11 million more in the UK, meaning 6 to 8.5 million cases of diabetes, 5.7 to 7.3 million cases of heart disease, 492,000 to 669,000 additional cases of cancer in the US and UK combined. The combined health care costs increases are $48-66 billion per year in the US and by £1·9-2  billion  per year in the United Kingdom. Health and economic burden of the projected obesity t… [Lancet. 2011] – PubMed – NCBI

Effects of Childhood Obesity Can be Reversed

November 17th, 2011

An analysis (published today in the New England Journal of Medicine) of over 6,000 subjects followed for 23 years found persons who were obese in childhood had high risk of type 2 diabetes, hypertension, elevated low-density and high-density cholesterol, triglyceride levels as well as carotid-artery atherosclerosis compared to persons who were never obese. However, persons who were obese as children but normal weight as adults had risk similar to those with a normal BMI consistently from childhood to adulthood. The New England Journal of Medicine: Research & Review Articles on Disease & Clinical Practice

Exenatide shows anti-inflammatory effect

November 2nd, 2011

A new study of exenatide, a drug for type 2 diabetes which can also cause weight loss, has shown a rapid anti-inflammatory effect, independent of weight loss, in a study of 24 obese diabetics. Participants also saw a drop in HbA1c levels from 8.6% to 7.4%  The anti-inflammatory effect may reduce the risk of atherosclerosis in patients with type 2 diabetes.Exenatide Exerts a Potent Antiinflam… [J Clin Endocrinol Metab. 2011] – PubMed – NCBI Exenatide has previously been shown to cause about a 6.6 kg (14lb) weight loss combined with a lifestyle modification program. Effects of exenatide combined with lifestyle modifi… [Am J Med. 2010] – PubMed – NCBI

AHRQ Seeking Comments on Bariatric Surgery

October 21st, 2011

The federal Agency for Healthcare Research and Quality is seeking comments on an evidence report comparing bariatric surgery to other modes of treating adults with obesity with a BMI between 30 and 35 with metabolic comorbidities, such as type 2 diabetes. The draft report finds moderate strength evidence for Roux-en-Y, laproscopic gastric banding and sleeve gastrectomy for resolution of type 2 diabetes at least in the short term.

The comment period is open to November 16, 2011. See Research Available for Comment | AHRQ Effective Health Care Program

Diet Trumps Physical Activity for Glycemic Control

July 8th, 2011

A new study published in The Lancet shows little advantage of physical activity over diet for glycemic control in newly diagnosed type 2 diabetics.  The study compared three groups: usual care, diet only and diet and physical activity. Both interventions did better than usual care but physical activity did not confer additional benefit. Diet or diet plus physical activity versus usual care in patients with newly diagnosed type 2 diabetes: the Early ACTID randomised controlled trial : The Lancet Other studies have shown more benefit from physical activity. Further, usual care involves dietary counseling and the intervention here involved more intensive dietary counseling. So this trial may actually attest to the importance of more intensive behavioral counseling. Diet and exercise for new-onset type 2 diabetes? : The Lancet