Posts Tagged ‘weight loss’

FDA Approves Once Weekly Drug for Diabetes; Shows Weight Loss

January 28th, 2012

The Food and Drug Administration has approved Amylin Pharmaceutical’s Bydureon for thetreatment of type 2 diabetes. This is the first once-weekly treatment for type 2 diabetes. It is hoped that this feature will lead to higher adherence to the treatment regimen, although as with Byetta, it is injectable. The drug is exenatide, a GLP-1 receptor agonist. Study results showed an improvement in glycemic control.  A1C levels, a measure of blood sugar, decreased an average of 1.6 points.

Many patients with Type 2 diabetes are also overweight or obese. Many drugs for type 2 diabetes actually cause weight gain. The advantage of Bydureon (and its daily administered counterpart, Byetta) is that patients taking Bydureon can achieve weight loss, in addition to improvements in glycemia, blood pressure, and cholesterol in both overweight and obesity subjects with and without type 2 diabetes. Effects of glucagon-like peptide-1 receptor agonists on … [BMJ. 2012] – PubMed – NCBI

A very small study of 12 children and adolescents with extreme obesity also showed significant improvements, suggesting the need for a larger study. Exenatide as a weight-loss therapy i… [Obesity (Silver Spring). 2012] – PubMed – NCBI

More information is available at www.BYDUREON.com.

New Analyses Cast Doubt on Fruits, Vegetables, Physical Activity to Control Obesity

July 24th, 2010

July 24, 2010

A review of the relationship between fruit and vegetable intake with adult and childhood obesity casts doubt on how strong is the relationship with weight management. The review was undertaken by TA LeDoux and colleagues from the Department of Pediatrics at the USDA/Agricultural Research Service Childrens’ Nutrition Research Center at Baylor College of Medicine.

They found that, after reviewing 772 studies, increased food and vegetable consumption (in conjunction with other behaviors) contributed to reduced adiposity among overweight or obese adults but no association was shown among children.

While the quality of the studies varied widely, the relationship between high fruit and vegetable consumption and low obesity among “was weak” and among children “unclear.”

The study can be accessed at Relationship of fruit and vegetable intake with ad… [Obes Rev. 2010] – PubMed result

In a separate study, doctors in Plymouth, United Kingdom following 202 children for 7 to 10 years, found that overweight preceded physical inactivity, not the other way around.  As most childhood obesity interventions assume inactivity precedes obesity, this study, if validated, indicates a change in strategy to combat childhood obesity. See Fatness leads to inactivity, but inactivity does n… [Arch Dis Child. 2010] – PubMed result

Goals

September 27th, 2009

5-10% is a realistic and achievable goal for weight loss Weight-loss outcomes: a systematic review and meta…[J Am Diet Assoc. 2007] – PubMed Result

What interventions should we add to weight reducin…[J Hum Nutr Diet. 2004] – PubMed Result

The weight stability approach Obesity in primary care: evidence for advising wei…[Br J Gen Pract. 2008] – PubMed Result

Do physicians support 5-10% reduction? What do physicians recommend to their overweight a…[J Am Board Fam Med. 2009 Mar-Apr] – PubMed Result

Look Ahead trial shows promising results from intensive weight loss counseling One-year weight losses in the Look AHEAD study: fa…[Obesity (Silver Spring). 2009] – PubMed Result

5% reduction needed to improve metabolic parameters Degree of weight loss required to improve adipokin…[Metabolism. 2009] – PubMed Result