Results of Look Ahead Published

June 26th, 2013 by MorganDowney Leave a reply »

As indicated on October 22, 2012, the Look Ahead trial was stopped early on the basis of futility. Now, we have the results of the study in the New England Journal of Medicine, June 25, 2013. The trial was a long-term study of intensive lifestyle intervention for weight loss to see if that would decrease cardiovascular morbidity and mortality among patients with type 2 diabetics. After 9.6 years, the study was stopped. While weight loss was greater in the intervention group than in the control group (6.0% v. 3.5% at study end), the intensive weight loss did not reduce the rate of cardiovascular events. The lifestyle intervention did reduce HbA1c, improve fitness and all cardiovascular risk factors except for low-density lipoprotein cholesterol levels. In addition, earlier reports indicated that the lifestyle group was more likely to have a partial remission of diabetes during the first 4 years of the trail than those in the control group and also showed reductions in urinary incontinence, sleep apnea, and depression and improvements in quality of life, physical functioning and mobility.