Posts Tagged ‘Louisiana Obese Subjects Study’
October 7th, 2011
The “obesity paradox” refers to a phenomenon in which overweight and obese patients with established cardiovascular disease have a better prognosis than normal weight patients. This has been a controversial finding in several studies, indicating to some that weight loss is worse than weight gain. Now, researchers from the Veterans Affairs Palo Alto Health Care System, examined 3,834 male vets. They did find that weight loss was related to higher mortality and weight gain was related to lower mortality, compared to stable weight over 7 years.
However, 60% of the deaths in the weight loss group were attributable to conditions associated with muscle wasting, including cancer and heart disease. These conditions arose during the seven year period. This study underscores that the obesity paradox may be explained by the distinction between intentional v. unintentional weight loss. As the authors note, clinically supervised intentional weight loss has shown extensive benefits including lowers incidence of cardiovascular events, better overall survival, marked reduction in the metabolic syndrome, inflammatory markers, lipids, prevalence of hypertension and better glucose tolerance. The obesity paradox and weight loss. [Am J Med. 2011] – PubMed – NCBI
Even very obese adults can improve their cardiometabolic risk factors. Researchers of the Louisiana Obese Subjects Study (LOSS) found most parameters improved with 5% weight loss or more among 390 extremely obese men and women, followed for one year. The intervention group was under primary medical care, using meal replacements, weight loss medications, especially sibutramine and behavioral counseling. Those in the intervention group lost an average of 13% of their weight while the ususal care group lost an average of 0.9%. 20.7% of participants had substantial weight loss (10%-19.9%) and 15.4% lost over 20%. There was a “precipitous” decrease in fasting plasma glucose among patients with type 2 diabetes who achieved at least modest weight loss. Systolic and diastolic blood pressure decreased inconsistently. With modest weight loss, patients achieved 22% improvement in triglyceride levels. Only 53% of subjects stayed in the program for evaluation at one year. Incremental weight loss improves cardiometabolic ri… [Am J Med. 2011] – PubMed – NCBI
A similar result has been observed in severely obese subjects in the Look AHEAD trial. Effectiveness of Lifestyle Interventions for I… [Diabetes Care. 2011] – PubMed – NCBI